The therapeutic benefits of psychedelic substances like psilocybin and ketamine are attributed to their interaction with serotonin receptors, specifically the 5-HT2A receptors. By binding to these receptors, psilocin and ketamine activate a cascade of events that lead to changes in neuronal signaling, resulting in subjective effects and potential benefits for psychotherapy.
One theory suggests that psychotherapy activation prompts a temporary breakdown of established neural pathways, allowing for new connections to form. This disruption can help individuals break free from rigid patterns of thinking and open up new possibilities for personal growth and healing during a focused therapy session or psilocybin session with psychological support.
Research suggests that psychedelic-assisted psychotherapy enhances emotional processing by increasing amygdala reactivity while simultaneously dampening default mode network activity. This unique combination allows individuals to confront difficult emotions within a safe therapeutic setting and potentially find resolution or acceptance with the help of psychological support and psychiatry.